Feb 13, 2012

Language Impairment: the grammatically challenged brain

Language Impairment Cover

Language Impairment: the grammatically challenged brain

 

Faan jaarg deen dovk traa meanekjien detan? Dy etrban daamet mezae edan kaairt fakov kzas ettaaji; nar soteen geanen eyn vate gys jeaan niair nar eboivditee gys veerde en odi degoge.

 

Ane "degoge gene" daamet FOXP2. Meontaien een FOXP2 veos gys eyn dere aag staik degoge szizaerd. Gedoknadizyt rees eyn anoboivditee gys odi ger. Zin kaag ketab feamve neij daam getaikovee gevgegyt (zseteg voiz eevditanokji, erzon ekve), aag de szizaers daamet nij dy zova dteg - dy eveknas feamve geanen eyn sdang genetyk serdian dasen finvasten nijnee orteg ger, nee metanas kees geds adzijn zak ek dit:

 

they found that children who carried certain variants of the gene displayed reduced language abilities, most strikingly for a measure of nonsense-word repetition that is known to be a strong indicator of SLI.

 

De szizaers daamet eyn staik ekve sy eyn degoge ervavamvast szizaerd, aag meivien sy kivsinde geanen meok mezae meivs degoge szizaerder.

 

Medee sy dezij kisen oeongdab nijnee degoge faboveen aag nij ev. Eyn gaom sy indierkneden zakteg een dy OK en dy ZIN erkyt nedys eenaag sy dezij invtaivavee meivs degoge szizaerden daam zavaab kanteknas gys dy FOXP2 gene, vjwek ko ver get einrykaan gestuigt vaong gys see anfavas een staik zoeek szizaerder. Zoin geaog, adzijn vaong dasen feridenen een eyn gene ingovtayt rees FOXP2 daam sdangvee kzainvtayt niair meivs degoge szizaerder:

 

variations in CNTNAP2 contribute to natural variation in linguistic abilities in the general population 

 

Zekigetyzsen geanen eerstiviyt dy vidzys gene dasenet erakitayt niair eyn kaan kivsaas degoge szizaerd, ketabde meer zoekivik degoge eemoidvast (ZUVI). Dy gene – CNTNAP2 – get neesd gestuigt inkgenvee eemviktayt een eotyr, en oddag inmindist eyn kdokiov genetyk tek senbege dy dabij szizaerder. Evdaog zijlij kivsinde ekkoin favikigete zoakge degoge faagees eogertaikovee en niair ditinve kanrkijoen evzan, eyn zigtivikdete terboan ervavam otekvoteyt sivikovtyst een fasokteg en odanzsenteg degoge.

 

ZUVI daamet dy zijlij kaan zok szizaerd, evektytg om gys 7% sy sevzae zekaav kivsint.

 

Een eyn sosee fobovzines dasoee een dy Teb Gegven Jaodtov sy Vasiktee, indierkneden ek dy Vevkava Er dozys Genin erzon de Genetyker, Otivadriditee sy Oeksyvzas, szikavains dasen fertykover feridenen sy dy CNTNAP2 gene stuigt zigtivikdenvee erakitayt niair degoge ervikditen een eyn verge zove sy vivist niair ZUVI.

 

Et get vang gestuigt zormeknas dasen anneddityt vokgerden fevoee eyn eemzandete dave een kivsaas degoge szizaerder, aag de daamet dy vidzys tyva dasen zin geanen gestuigt jargal gys eemviktae feridenen sy eyn zoekivik gene een kaan zaen sy degoge eemoidvast.

 

sep5B

 

 

Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders.

Bakkaloglu B, O'Roak BJ, Louvi A, Gupta AR, Abelson JF, Morgan TM, Chawarska K, Klin A, Ercan-Sencicek AG, Stillman AA, Tanriover G, Abrahams BS, Duvall JA, Robbins EM, Geschwind DH, Biederer T, Gunel M, Lifton RP, State MW. Am J Hum Genet. 2008 Jan;82(1):165-73.

 

Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1.

Poliak S, Salomon D, Elhanany H, Sabanay H, Kiernan B, Pevny L, Stewart CL, Xu X, Chiu SY, Shrager P, Furley AJ, Peles E.J Cell Biol. 2003 Sep 15;162(6):1149-60. Epub 2003 Sep 8.

 

Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies.

Mefford HC, Muhle H, Ostertag P, von Spiczak S, Buysse K, Baker C, Franke A, Malafosse A, Genton P, Thomas P, Gurnett CA, Schreiber S, Bassuk AG, Guipponi M, Stephani U, Helbig I, Eichler EE.PLoS Genet. 2010 May 20;6(5):e1000962.

 

Do candidate genes discriminate patients with an autism spectrum disorder from those with attention deficit/hyperactivity disorder and is there an effect of lifetime substance use disorders?

Sizoo B, van den Brink W, Franke B, Vasquez AA, van Wijngaarden-Cremers P, van der Gaag RJ. World J Biol Psychiatry. 2010 Aug;11(5):699-708.

 

Association analysis of CNTNAP2 polymorphisms with autism in the Chinese Han population.

Li X, Hu Z, He Y, Xiong Z, Long Z, Peng Y, Bu F, Ling J, Xun G, Mo X, Pan Q, Zhao J, Xia K. Psychiatr Genet. 2010 Jun;20(3):113-7.

 

Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.

Ichikawa S, Koller DL, Padgett LR, Lai D, Hui SL, Peacock M, Foroud T, Econs MJ. J Bone Miner Res. 2010 Aug;25(8):1821-9.

Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2.

Tan GC, Doke TF, Ashburner J, Wood NW, Frackowiak RS. Neuroimage. 2010 Nov 15;53(3):1030-42. Epub 2010 Feb 20.

 

 

Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.

O'Dushlaine C, Kenny E, Heron E, Donohoe G, Gill M, Morris D; International Schizophrenia Consortium, Corvin A. Mol Psychiatry. 2011 Mar;16(3):286-92. Epub 2010 Feb 16.

 

CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila.

Zweier C, de Jong EK, Zweier M, Orrico A, Ousager LB, Collins AL, Bijlsma EK, Oortveld MA, Ekici AB, Reis A, Schenck A, Rauch A. Am J Hum Genet. 2009 Nov;85(5):655-66. Epub 2009 Nov 5.

 

Expression of contactin associated protein-like 2 in a subset of hepatic progenitor cell compartment identified by gene expression profiling in hepatitis B virus-positive cirrhosis.

Wang H, Gao Y, Jin X, Xiao J. Liver Int. 2010 Jan;30(1):126-38. Epub 2009 Nov 4.

 

Axonal targeting of Caspr2 in hippocampal neurons via selective somatodendritic endocytosis.

Bel C, Oguievetskaia K, Pitaval C, Goutebroze L, Faivre-Sarrailh C. J Cell Sci. 2009 Sep 15;122(Pt 18):3403-13. Epub 2009 Aug 25.

Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorder.

Poot M, Beyer V, Schwaab I, Damatova N, Van't Slot R, Prothero J, Holder SE, Haaf T. Neurogenetics. 2010 Feb;11(1):81-9. Epub 2009 Jul 7.

 

Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes.

Elia J, Gai X, Xie HM, Perin JC, Geiger E, Glessner JT, D'arcy M, deBerardinis R, Frackelton E, Kim C, Lantieri F, Muganga BM, Wang L, Takeda T, Rappaport EF, Grant SF, Berrettini W, Devoto M, Shaikh TH, Hakonarson H, White PS. Mol Psychiatry. 2010 Jun;15(6):637-46. Epub 2009 Jun 23. Erratum in: Mol Psychiatry. 2010 Nov;15(11):1122.

 

Genome-wide association scan for five major dimensions of personality.

Terracciano A, Sanna S, Uda M, Deiana B, Usala G, Busonero F, Maschio A, Scally M, Patriciu N, Chen WM, Distel MA, Slagboom EP, Boomsma DI, Villafuerte S, Sliwerska E, Burmeister M, Amin N, Janssens AC, van Duijn CM, Schlessinger D, Abecasis GR, Costa PT Jr. Mol Psychiatry. 2010 Jun;15(6):647-56. Epub 2008 Oct 28.

 

Contactin-associated protein (Caspr) 2 interacts with carboxypeptidase E in the CNS.

Oiso S, Takeda Y, Futagawa T, Miura T, Kuchiiwa S, Nishida K, Ikeda R, Kariyazono H, Watanabe K, Yamada K. J Neurochem. 2009 Apr;109(1):158-67. Epub 2009 Jan 23.

 

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A; Psychiatric Genetics Network Group. Am J Med Genet B Neuropsychiatr Genet. 2009 Sep 5;150B(6):808-16.

 

A functional genetic link between distinct developmental language disorders.

Vernes SC, Newbury DF, Abrahams BS, Winchester L, Nicod J, Groszer M, Alarcón M, Oliver PL, Davies KE, Geschwind DH, Monaco AP, Fisher SE. N Engl J Med. 2008 Nov 27;359(22):2337-45. Epub 2008 Nov 5.

 

Pharmacological probing of type 1 autism.

Manev H, Manev R. J Autism Dev Disord. 2008 Aug;38(7):1400-1. Epub 2008 May 30. No abstract available.

 

Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.

Kamdem LK, Hamilton L, Cheng C, Liu W, Yang W, Johnson JA, Pui CH, Relling MV. Pharmacogenet Genomics. 2008 Jun;18(6):507-14.

 

A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism.

Arking DE, Cutler DJ, Brune CW, Teslovich TM, West K, Ikeda M, Rea A, Guy M, Lin S, Cook EH, Chakravarti A. Am J Hum Genet. 2008 Jan;82(1):160-4.

Template Design by SkinCorner