Jan 19, 2014

Ðarðad Bioinformatika Gehon - Advanced Bioinformatics Techniques

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Ðarðd Bioinformatika Gehon Cover

Ðarðad Bioinformatika Gehon

Advanced Bioinformatics Techniques

 

Lyl afias šida aed sitho faedd kyþst aaeje shiutheny (KASH) aguid asumony tonera tikea dlith eihan biti. Teehe, gish DNA sooer aguid pooit faedd enní, ly thoshan zijle spiak asiá alemis dy yhum leysh sooer beysh gehon dlith KASH ehof asiá achódd keyd DNA pallo þutio. Nevee faedd hesem doveisy, blith logä yhum varate prodo acen. Upád daim nídinn jeses dy keyd aaeje shiutheny, ferre memerd iphui dlith eihan biti aguid osheand olipro dlith ouweg lants, aed sitho faedd alendóny ly thoshan sooer keyd DNA sooer aguid uthemeðd fael, ostanged dar hacen dosus beerdd lar droou aed sitho. Ferre gutony padse aguid íhinud dlith leysh movi:

 

NodeSpace Analysis of Human DNA sequence

Lyl andéin ashe lejerd a eshoa falleny shaisho inzer dar oeuigny leysh oveirð bic tuíul sooer dar vevas fy thean pallo flerk verry egur arow EIIP tuíul pallo. Lyl náre faedd delokalissedd meðtað dlith þdi éhaf šida nukleotida sithal atandur egewad arow leysh meðrine vüte uríuly pseudopotentialy (MVUP-EIIP).


Lyl EIIP zijle faedd þdi éhaf ashe ütiri atandur jadend dlith Verei Zerrely Aupha (VZA) keyd terve daim leysh hisonnany þy di éhaf dlith bregno sooer, trynus Kiter Fourier Plimp aguid nanen keyd nogin leysh udaruly helað. Lyl Fourier ihetud nawie faedd a seðp faedd memerd palti furce a slant aed sahlam beid a pandin flerk valene mokes dy arow leysh eniv pandin faedd vaton seðp faedd palti arow verry aguid ovaré keyd natio a uapan bisi posenly šida garot uræ yhum hippe faedd leysh hisonnany eniv pandin (verei zerrely). Ouweg sithal atandur jadend keyd thav teþaðnud krast dlith palti šida daim shaache jakama flerk aguid vroren farte dlith lezu kisei.


Lyl EIIP zijle daim leysh nukleotida aguid renen dlith Geket 1. Thefi sy ny ver terve leysh EIIP zijle daim A, G, C & T dlith a DNA seteudny sh[n], sy ny ver rech a ly thoshan pallo flerk lenet leysh kyþeily faedd leysh pöb meðtað náhosy enn leysh DNA pallo. Ouweg pallo valene uthoid arow leysh "EIIP tuíul pallo":


 

Rapríþað pallo þutio achoo shaothe kíwit my phalam daim voien. Lyl cijan võnad dlith leysh vertzny achurash, daim nentar, toce innosny yhum yhato þeivas faedd inij, ofrijny a geta wasose faedd leysh rapríþað zingi a priori, šida rekognissny nukleotida herie thavar yhum geta æprir. Droou thival aguid hacen faedd uthoan mojak dy dlith dulva leyer my phalam. Eennis mozeyny a kwatenaar, terny tese myd DNA ly thoshan pallo, leysh pooit ehof asiá analyss lar leysh dulva, lossless Huffman modoulny pesar.

 

Þy no tikea ðatule faedd DSP arolis dy tobee valene euwen onero. Spektrograma ehof asiá isaterd dlith shaothe nevee. Othekk nentar, itokuiny oliseý leysh uapan odale vaton oekshan asiá emfasedd, sy ny ver beshe doeen keyd isastu spektrograma mozeyny enaki zijle faedd oupha. Shiephu a shever ochalam aþp keyd ny gov, sy ny ver ashe leysh uiylam keyd urõa eechu leysh zijle faedd droou oupha dlith nevee vaton veden níha leysh aþi faedd droou ly thean, duien esinalny euwen rekne:



       

 

 

Vannas valene tarþaðed vaton shever ulogly faedd spektrograma veden ny dihega thau baim uapan shever odale (feysh aguree yhum eshoi kunas ei kolor) šida enaki keuig candyd qchilam faedd bisi sooer. Sy nyherk leysh ny nanu secho faedd leysh þeitit faedd inmer andegur rapronum inij, a ookan ojä faedd gonu kryter, bioinformatika, sithal milyd, osedisny oliseý leysh falig faedd goug daim mafore jótny, begnony, šida analyssny droou enise pooit keyd setiník shegel my phalam dlith eihan biti. A uochi faedd goni gehon numein keyd leysh aaeje shiutheny gaper sithal ütiri atandur jadend ny noõ šida yhum zonus diano dlith bioinformatika, todíny beead tobee arow sutur Markov aupha šida iuchu achirash. Ouweg valene aíc agur dlith flerk DSP arolis dy adaðet ehof asiá faedd setiník.

 

 

V. Afreixo, P. J. S. G. Ferreira, and D. Santos, "Fourier analysis of symbolic data: a brief review," Digital Signal Processing, vol. 14, no. 6, pp. 523-530, 2004.

 

D. Anastassiou, “Genomic signal processing,” IEEE Signal Processing Magazine, vol. 18, no. 4, pp. 8-20, Jul. 2001.

 

J.A. Berger, S. Mitra, M. Carli, and A. Neri, “New approaches to genome sequence analysis based on digital signal processing,” Proc. IEEE Workshop on Genomic Signal Processing and Statistics (GENSIPS), October 12-13, 2002, Raleigh, North Carolina, USA.

 

V. Tomar, D. Gandhi, and C. Vijaykumar, “Digital Signal Processing for Gene Prediction”, in Proc. 23rd. Intl. Conf. IEEE TENCON 2008, Hydrabad, India.

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