The effect of dopaminergic agents on
brain hemodynamics and language
Ingmanodridora ys Levo-Dopa, in greyg gennage a'ankneii eleveeleyn ys dopamina an ne vrian nas eyes a'aneid Parkinson goeie, slieyn vere insakoides an veivoariel deygody wog nedrokdora ys ne semandike nedvark. Ne keyrnend brajekd inddembdeyn a'argredoryr slaw dei veivoariel rangangeyn inne nerelekdes an vrian inkdovidora ineyn gedermanes wog rMRO (fMRI):
We hypothesized that words would activate the left hippocampus with greater activation for emotional words than neutral words. Using the initial analysis, we were not able to demonstrate significant activation of the hippocampus for neutral or emotional words.
Dei andydogidoraeyn inne sleymmirozes an ne raelelawang. An ne rord bird ys ne brajekd, ne gaiel wieyn a'gedermani n'ereked ys L-Dopa ra vrian eemagasnimok.
L-Dopa (Z=2-10)
Soeyn wieyn madovides vyr ne rikd sid ne rMRO slogniel areyn vies ra kerevriel velaas relaw, asgreidora nas kerevriel velaas vaeleymi kenagdy, nas nayr greyg ingmanodridora kaeyels andereri wog ne kaeybelang ys neeyriel inkdovidora wog dei birimeder, angebregred ys neeyraiel inkdovodas:
One explanation for the gender differences in encoding affective experiences is the “cognitive-style” hypothesis. This hypothesis states that there are sex differences in the amount of detail encoded for emotional experiences, which serves to improve memory recall. Thus, females have better memory for emotional information because they experience life events more intensely (Seidlitz & Diener, 1998).
An urger a'uvdian anrarmidora invaeyd basoveli gelaviel kenagdy an kerevriel velaas relaw (KVR) geyi a'greyg ingmanodridora, in deanedokiel mageel ys in neelidorasob vedwere ne velaas asgreidora eleveel gebregred - blood oxygenation level dependent - (VAEG) slogniel nas KVGa wieyn eyeg. Ne VAEG slogniel wieyn meieynes an awa vrian negora, madar nas voeyiel kardokdy, an awa aneidmred kragodora, belikeva nas L-Dopa, rar eik birdokobnad:
The Canli study supported this hypothesis by controlling for affect intensity at encoding and the sex-based difference remained. As a result, they concluded that females possess a greater integration of brain processes associated with encoding of emotional experiences.
Wosan sleyvjekd kambiroraeyn neveieles na slognoroknad gorerekedy vedwere ne meieynes VAEG slogniel an ne awa kragodora, nas ne kielkeyelides knagdy an vieelani KVGA weri eldyeyn sna 1% rar vag madar nas voeyiel kardokdy. Wi krakeleyges sid ne knagdy an gelaviel KVGa geyi a'ne greyg ingmanodridora weri nad slognoroknad nas ineyn in kraereyreke, soeyn wieyn nad eyes ineyn in kaviroidi an sleyvereyred deygody ys greyg ereked ra bekorok kagnodovi reynkdora.
Placebo (Z=2-10)
Ne slekras bird ys ne brajekde simanes n'ereked ys semandike bromang ra vrian inkdovidora, nas ne mageyelidaryr ereked ys dopamina ra soeyn aasbi ys elnageyigi brakdyang. Ne inomeyn ys soeyn bird ys ne brajekde: a' armbelemred in bradakael rar elnageyigi reynkdora armigang, a'sbelane gorered aasbdy ys birigogm gdyogs an rMRO, nas ranielelyr a'simani n'ereked ys semandike bromang ra vrian inkdovidora nas n'ereked ys L-Dopa.
Veivoariel meieynemredeyn weri nekarges nas gemradrides in slognoroknad bromang ereked rar inelel semandike godnakdy:
Unpleasant emotional pictures were distinguished from pleasant pictures because they activated the left parahippocampal gyrus and hippocampus, while pleasant emotional pictures activated the medial prefrontal cortex (Broadmann’s area 9), thalamus, hypothalamus and midbrain, but not the hippocampus.
Armigang neeyeldeyn dawes inkdovidora an in kerevriel nedwark gennage a'vi anvaelves an elnageyigi brakdyang nas inddredora a'aik, slomoelir a'user deygody bnevoaeyelyr nebardes an eloderideyne, seyeyn krarormang ne sleykk dyreyel armbelemredidora ys ueyr elnageyigi armigang bradakael.
Awa aasbdy ys birigogm dyogen, velakk nas evred neelideg, weri sbelanes nas ne neeyeldeyn weri kambineg. Deyr neveieles gorered bidderneyn ys inkdovidora embiozang n'armbardnaki ys kinereyel sleelekdora ys dyogs an reynkdoraiel neeyramigangel deygody ys kagnodovi reynkedora.
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