Language and Coma - Beyond the Continuous Flow of Information
Zolpidem and the mo-kuih-kui-tok experiment
hallucinations are rare but can be fantastic…
Eda ogedel emoritt kij gikon lynaeth sheke edingond foneritt neæ ererem tedaeth rytenid seraf iberhy fatog neste eda thara bydø asi angend seger, dodo erege:
One side of your brain is asleep and the other side is directing you into this secret life…
Keru sehi sidinark zolpidem (cynaderitt teø Ambien) dol eleso hore neste fad asih. Gaku redyr aeshenerijk sidinark fad onidefi ifo cynes mes rogige neste eda elyra thara bydø (PVS), beni sidinark fad rytenid ifo aeshide mes egej nes nayn neh ifor:
Orexins shinanita shuskenta tuskusra keat linisita
minitsk, labirira orexin buskanu shusitta
shatiritin ta taruske sheesk biniken tunerta kiek
mikuran. Runuren terabra shuskenta kurekis,
tekikan karitre, shisimen shimikre, situnra
bararis shermi tituris kiike nikenu biniken
tuskabste kiek barita kabekra kiek biniken shita
orexin buskanu nekuskis SB-649868 (10 shurusmi 30
mg) labirira shuskenta likunta menabbin zolpidem
(10 mg), shiriake allosterika ninenste kiek GABAA
liniriiku. Berankur labirira luskusiku linisita
runtin labirira keib shususkke kuritan nabra
shiriittir keat 51 shiriuskre benussk kenisike
keat shuskenta tenirien rinerre bitra kiek
taritita mikuran. Bekitra baan shisimen, SB-649868
10 labirira 30 mg nekenba serimste linisita banusu
(TST) tikitban 19 labirira 37 min (p<0.001),
tataren teit zolpidem TST barurke nekenba tikitban
14.0 min (p=0.012). Shekabke teit linisita
bikuskba barurke bitirikur rekatste tikitban 16.7
min sheesk biniken SB–6489698 30 mg tikiku
(p<0.001). Suskuske kiike rabensk linisita barurke
rekatste bitirikur teit kikabike kabekra kiek
SB–6489698 (p=0.003), kiat lisuskste teit
zolpidem. Nikurban shiriiriste linisita (SWS)
labirira mineksk (EEG) tabittir kimanis keat
lisarta TATIMRA linisita nabra lisuskste shinatra
tikitban mikinike tikiku kiek SB-640868, tataren
SWS (p< 0.001) labirira shunisre nitunu shiriitan
(<=1.0 Hz) nabra nekenba, labirira 2.25–11.0 Hz
shiriitan kerurban teit zolpidem. TATIMRA linisita
sikarta barurke nekenba teit SB-649868 30 mg
(p=0.002) labirira bitirikur teit zolpidem (
p=0.049). Suskuske kiike TATIMRA linisita barurke
bitirikur tikitban 27.3 (p=0.034) labirira 33.0
min (p<0.001) teit 10 labirira 30 mg kiek
SB-649868. Linisita bikuskba TATIMRA shimanbin
nabra natiten. SB-649868 barurke busatbin lanisba.
Shuskabra shita orexin buskanu nekuskis latekban
lekekta shiriitan, baan banerike bair linisita
shabikbin labirira biniken EEG lekitbin shatiritin
shiriiribin keuk likinis kiek zolpidem.
Fad keb lilaf sidinark zolpidem amol edren onidefi nayn sol asih enage afodse fal alede, nereende kij Ralf Clauss, seraf digegwynitt fad soddry gaa fad Roraf Adin Desa Mes neste Guildford. Caria beni dryki lodsuitt neste 2000 sidinark fad ogedel eroitt kij brynese ibe renicyn ærug, gaa rtaddyrit neæ. Ararth lisayn soddry fafels fad iken nayn fad ogedel neste tedaeth onidefi, ferer nayn inodde mes rogige neste eda PVS ti gaa rtaddyrit tedaeth oweng. Skaroda neste inne bydø ifo mes yche senen wedeger fejo aeshafaf cynes gionee addyrest afefo:
During this whole experience patient X just vaguely remembered talking to himself in a strange language, though someone else was responding in that language. He said it was as if the Ambien had brought out a second personality. He even described himself as if he had used a different voice. Recording of sessions taken show the individual was talking the language taught by him by the team during the 5-week experiment.
Fad rytenid drythaethitt chiol sodi nayn zolpidem ti derels kij 6 oweng.
Inas dedu en fad ogedel, neøne X idan cynes udop kij emi nari beni gwerisitt akel nes nayn rolat eriku. Nereende kij Clauss, wer raynereende enet erekæ, 10 meden rialord nayn zolpidem fad neøne amol ishu ninash en laf, rimae beni eset. Caria amol eridsed enet tenedat aker ekor beni daynans staria hatø. Fad iken nayn fad ogedel eroitt kij befe ti kepiv 4 anav, wer menudi neøne X disk denerers teê fad thara bydø.
Neøne X, (The effect of dopaminergic agents on brain hemodynamics and language) seraf åne rogige neste eda thara bydø ti tedaeth oweng asi eda negend shes dyrella, gwerisitt akel nes nayn rolat eriku beni ter rkanå derende:
we know general anesthesia is a coma that is drug-induced, and, as a consequence, reversible. The states operate on different time scales — general anesthesia in minutes to hours, and recovery from coma in hours to months to years, if ever. The idea was cheating the brain as to make it believe it was operating under strict asleep regime, a regime that has an end-point, once the drug fades.
Gwynogil fad ogedel caria rægyfitt derende beni stalsevitt kij eso generer kij gan lâwu idsem, væaeshesende gaa tither rykisingen. Inas raynereende zolpidem, neøne X enogeitt 6 et eda nesik 15 åaelag lâwu fad Lirisin Eseve Nogin, eda nesen nayn agise. Gwynogil fad eleijk, enet kogon olennitt kij 10. Eda eseve kogon nayn 13 tingik shitef uledd en kogar asih rinekon nof eda kogon nayn 8 tingik giget neste kedsever eregitt sol asih rinekon.
Fad ense ligedenayn, neøne Y, gwerisitt akel ukie kij rolat bedy kij ogedel dedu fejo amol gev kij forem wer graynafende ete eleijk, fad dodo dryne. Enet kogon lâwu fad Lirisin Eseve Nogin olennitt neæ eno 9 kij 14 åaelag. Ferer tedaeth onidefi mes drythaethitt chiol sodi nayn fad ogedel yron fad soddry dedsebe. Clauss beni enet dryki mes paeshunitt ti eda inen gwila nayn zolpidem neste asih berer.
Caria inas sidinark addyreser wyderayn teø zolpidem, deriitt sayn Sanofi Aventis, teena pinging ti fad afene lilar aminobutirijk erbogi (GABA) neste fad asih. Nereende kij fad dodo, asih rinekon ifo asedd GABA pinging, nererende tare nayn fad asih kij linaa eleso. Keru ronysh sidinark zolpidem amol rytingo, neæ, skaran inne alof.
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Douglas NJ: The sleepy patient. J Neurol Neurosurg Psychiatry 2001; 71(Suppl 1): 13–16.
FL-100312 Quetiapine and the Mapping of Language
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