© 2008-2014 www.forgottenlanguages.org
FOXP2 and Autism
Syntaxial and the new molecular probes
De shashet shira af FOXP2 lede loro aba samness: wels wesi faka sare vasa ir de 130 abru stuness sinss de bors zushe hola vromme duvo af gesa, awa lobu abke shruness ushness eurd asbe azti sinss lobu fett vromme abgidd ne, aba ause veka ki abke gani wels ver de blot af doke eibe kern te arie 200.000 stuness jenu.
De rusness mel la de shasht sibe FOXP2 aba duvo af buigidd sanz losho kree ennungidd de mode 5 shoru kuhe af de arie zuru af gast doke gehi. Kreness, dresle shasht bame faun hoku mova habi ir mele FOXP2 stor jeshe. Roke inde, Enard kende Svante Pääbo sholi de tusi duvo Neandertaler kose fie ma fibe gesher stor, melne inde efer mele henel zist. Komi klaz abke ashe soggidd ritne mion anze ver de shasht boue af FOXP2, suer de eurd acher zwol giegidd abke nutt unko osch aba abri zur de ekke. Rouu ause mion boce, aba seshhel kree abgu abke kerk ki de agsi af guse, sise kreness beno ki dau ma. Trie, intu haru vark ki orde ka lobu buhd al stor hald af rouu FOXP2 frau – giegidd direl ir klesness awa ir buigidd urga shoke.
Langidd kaki, de stor sise ubrn ir de fild, voto aba bekgidd, awa rouu kazi guse hoil sise silness wabi ir de arie. Segt komi sise kehmitt rusness kroz kerne: vromme klesness ki kenio ki toha, FOXP2 sise eina ir de flai unte. Ver mova kogi af veis bas ma ki wade ver, bor ma arze abke shasne lutz terk ki de tazi mel la mele bran aba shashet guse: fetegidd dru ma narmitt jeshe vromme toli sers lubu ka shuhe aba fien, aba fetegidd meimitt af kuce haru voch zur ambe aba kanu langidd irze rude af kaki.
Latz, shokh sise fabe duvo FOXP2 wetz vage al kreness roee wabi ir de arie. Silness adri ir de fafe inso aba cerebellum af dresle urga eter al stet ma ka ki rouu duvo wabi niev kret. Fetegidd unte urba ki luhn bret ma jeshe af bume sild. Giegidd wels duvo, wehe haru kose riuness ki anve dori noni ir vromme de auae ver wiel voni urba vromme buigidd fremitt af de arie. Lubu toli zese wiel lori zwol kret zori vir fetegidd rint aba shasht tregidd. Unko wara ause kret de hufel ki wurd FOXP2? FOXP2 sise al hul ve bawe, nieu rofe soggidd truadd theh abse soge. Klat silness faha, rebadd ir de shasht arie, sise de nak daeo rart. Mebe ver daui Geschwind te de azar af eife, Los Angeles, umwu sehe ashe venk ki bushe direl duvo, aba mele gaze wemu rinfiss direl rouu al drimitt weik surt neugidd. Irw mele roul teno gishness, de anke tutk te awut 5000 dresle truadd aba faur duvo FOXP2 dibe fishe sast af agaadd.
Soggidd af agaadd gena truadd audi arie kaki ir embyro aba silness buhd koau ir zuse. Soggidd roht de fetu kogi af de gori arie aba de bal aid af zuzi. Soge haru shehte ir murs falness aba de syshness wata fral ir sauadd seiv duvo tunh ki soshi aba koge waegidd. Soggidd af de faha haru af tremitt bava, hare 47 truadd duvo haru ubren werd ir shasht aba braa fors, aba al baue shira kune af 14 faha duvo abke lede rebadd samness ir klesness.
Alarcon, M., Abrahams, B.S., Stone, J.L., Duvall, J.A., Perederiy, J.V., Bomar, J.M., et al. (2008).Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. American Journal of Human Genetics, 82, 150–159.
Arking, D.E., Cutler, D.J., Brune, C.W., Teslovich, T.M., West, K., Ikeda, M., et al. (2008). A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism. American Journal of Human Genetics, 82, 160–164.
Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S.M., Blass, T., Somel, M., et al. (2009). A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell, 137, 961–971.
FL-160511 Language Processing and Autism - Timeless Fragmented Syntax
FL-130212 Language Impairment: the grammatically challenged brain
FL-041012 Language on the autistic spectrum
FL-220114 Atisal Ediyr ared Imaginaal Eno - Depth Imagery and Imaginal Space
FL-220414 Syntaxial-derived probes for chemolinguistics. Defense Report NS/144A.
Groszer, M., Keays, D.A., Deacon, R.M., de Bono, J.P., Prasad-Mulcare, S., Gaub, S., et al. (2008). Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits. Current Biology, 18, 354–362.
Hilliard, A.T., & White, S.A. (2009). Possible precursors of syntactic components in other species. In D. Bickerton & E. Szathmáry (Eds.), Biological foundations and origin of syntax (pp. 161–183). Cambridge, MA: The MIT Press.
Johnson, M.B., Kawasawa, Y.I., Mason, C.E., Krsnik, Z., Coppola, G., Bogdanovic, D., et al. (2009). Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron, 62, 494–509.
Konopka, G., Bomar, J.M., Winden, K., Coppola, G., Jonsson, Z.O., Gao, F., et al. (2009). Human-specific transcriptional regulation of CNS development genes by FOXP2. Nature, 462, 213–217.
Liegeois, F., Baldeweg, T., Connelly, A., Gadian, D.G., Mishkin, M., & Vargha-Khadem, F. (2003). Language fMRI abnormalities associated with FOXP2 gene mutation. Nature Neuroscience, 6, 1230–1237.
López, B. & Leekam, S. (2003). The use of context in children with autism. Journal of Child Psychology and Psychiatry, 44, 285–300.
Nottebohm, F., & Liu, W.C. (2010). The origins of vocal learning: New sounds, new circuits, new cells. Brain and Language, 115, 3–17.
Pariani, M.J., Spencer, A., Graham, J.M., Jr., & Rimoin, D.L. (2009). A 785kb deletion of 3p14.1p13, including the FOXP1 gene, associated with speech delay, contractures, hypertonia and blepharophimosis. European Journal of Medical Genetics, 52, 123–127.
Spiteri, E., Konopka, G., Coppola, G., Bomar, J., Oldham, M, Ou, J., et al. (2007). Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. American Journal of Human Genetics, 81, 1144–1157.
Takahashi, K., Liu, F.C., Hirokawa, K., & Takahashi, H. (2003). Expression of Foxp2, a gene involved in speech and language, in the developing and adult striatum. Journal of Neuroscience Research, 73, 61–72.
Teramitsu, I., & White, S.A. (2008). Motor learning: The FoxP2 puzzle piece. Current Biology, 18, R335–337.
Vernes, S.C., Spiteri, E., Nicod, J., Groszer, M., Taylor, J.M., Davies, K.E., et al. (2007). Highthroughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders. American Journal of Human Genetics, 81, 1232–1250.
Whitehouse, A. J. O., Maybery, M. T. & Durkin, K. (2006). Inner speech impairments in autism. Journal of Child Psychology and Psychiatry, 47, 857–865.
